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As the level of evidence available is low, this necessitates larger well-designed trials to justify these interventions for patients affected by MRONJ. The current evidence demonstrate that, taking into account individual risk factors, teeth extractions can be harmless performed in patients under antiresorptive or antiangiogenic therapies because the origin of MRONJ appears to be more related to biofilm contamination than with the use or effects of any specific drug. Up to a quarter of patients with osteonecrosis of the jaw associated with antiresorptive agents remain undiagnosed. Histological character istics of osteonecrosis of the jaw. In subspecialty medical, radiology, and dental journals, case reports and case series described clinical features of osteonecrosis of the jaw in patients with cancer who were treated with bisphosphonates. Rats were sacrificed after 14 weeks. A potential alternative to drug holidays.
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